Chimie analytique : une revue indienne
ISSN (PRINT): 0974-7419

Abstrait

Validated stability indicating analytical method for the determination of clindamycin phosphate and adapalene in topical formulation.

M.S.Navkhare, H.K.Gaidhane, D.R.Chaple, P.L.Ingale, S.V.Ghodekar


A reversed phase liquid chromatography (RPLC) method has been developed for the separation of clindamycin phosphate and adapalene in topical formulation. The method used a Hypersil BDS, 5µm, 250 ï‚´ 4.6 mm i.d. columnmaintained at 35oC. Themobile phase comprises a) 0.1%OPA(ortho phosphoric acid) and b) THF (tetrahydrofuran): ACN (acetonitrile) at the ratio of 35:65 at a flowrate of 1.0mL/min.UV detection is performed at 210 nm. The method showed good ruggedness, robustness, linearity and repeatability. It is also suitable for formulation.


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