Abstrait

The definition of ibuprofen melting thermodynamic parameters with differential scanning calorimetry

E.V.Agafonova, Y.V.Moshchenskiy, M.L.Tkachenko

In the article the ibuprofen enthalpy of fusion and melting temperature data of different researches were analyzed. It was established that there were significant discrepancies between these data. Melting enthalpy and temperature corrections were carried out with Russian high-selective differential scanning calorimeter DSC-500. The experimental method of ibuprofen melting temperature and enthalpy definition was described. The calibration and results processing methods are also described.Melting entropy and cryoscopic constant were also calculated.