Abstrait

Synthesis and Characterization of Biologically Active Metal Complexes of Coumarin Derivatives

K. B. Vyas, K. S. Nimavat, G. R. Jani and M. V. Hathi

This paper reports the isolation of ML2 complexes, where, M = 3d5 to 3d9 elements and ligand L is 3-[{3-(3'-chloro)}-prop-2-enoyl] -4-hydroxy-6-methyl-2H-chromen-2-one. The metal complexes are synthesized and characterized by elemental analysis, IR spectra and conductivity measurements. All metal complexes are highly stable and non-hygroscopic. In vitro anti microbial activity of all synthesized compounds and standard drugs have been evaluated against four strains of bacterial culture and one fungus, which includes two gram +ve bacterial culture and two gram -ve bacterial culture, which show net enhancement in activity on co-ordination of metals with ligand but moderate activity as compare to standard drugs.