Chimie analytique : une revue indienne
ISSN (PRINT): 0974-7419

Abstrait

Synthesis and antimicrobial activity of substituted-1,3,2-oxazaphosphole 1- amines/oxide

K.Reddi Mohan Naidu, C.Naga Raju


Synthesis of substituted-1,3,2- oxazaphospholo 1- amines/oxides was accomplished via two-step process. It involves the preparation of mono chloride intermediate (2) and its subsequent reaction with various substituted aromatic amines/ heterocyclic amines in dryTHF in the presence of triethylamine at 50-55 ºC. These compounds were characterized by IR, 1H, 13C, 31P NMR andMS data.All the title compounds were found to exhibitmoderate antimicrobial activity.


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