Abstrait

Synthesis and antimicrobial activity of some S- nucleosides and Nnucleosides

Amira A.Ghoneim, Ahmed Fouad El-Farargy

Many of nucleosides have proved to be active anticancer, antipyretic and inflammatory agents. In the present work the reaction of 5, 6-diphenyl-1, 2, 4-triazine-3-thiol (1) with a blocked tri-O-acetyl-á-D-arabinosyl bromide (2) gave the corresponding nucleoside (3). We synthesized 6-tetra-Oacetyl- â -D-glycosidamino-2-methylthiopyrimidin-4-one (7), 5-amino-tetra- O-acetyl-â-D-glycosidamino-2-(methylthio)pyrimidin-4-one (9), 3, 4, 5, 6, 7, 8-hexahydro-4-(4-nitrophenyl) quinazoline-2(1H) thione and 2-(â-Dglucopyranosylthio)- 5, 6, 7, 8-tetrahydro-4-(4-nitrophenyl) quinoazoline (13) from pyrimidines derivatives with 2,3,4,6-tetra-O-acetyl-â-Dglucopyranosyl bromide. The structure of the newly synthesized compounds has been established on the basis of their analytical and spectral data. The biological activity of the prepared compounds was also described