Abstrait

Study on the electrochemical behaviour of apigenin and its interaction with DNA

Ming Zhao*, Guoxin Zhao, Yanli Liu,Hui Ni, Xiang Xu

The electrochemical behavior of the antitumor herbal drug apigenin was studied in 0.1 M B-R buffer solution (50% ethanol, pH 9.0) by cyclic voltammetry (CV), normal pulse voltammetry (NPV), chronoamperometry (CA) and chronocoulometry (CC) at glassy carbon electrode. In CV, only one irreversible anodic peak with Ep= 0.580V was appeared at scan rate of 50 mV/s and a new electroanalytical method for this herbal drug was established according to this anodic peak. Moreover, the electrode process dynamics parameterswere also investigated by electrochemical techniques and the possible electrode reaction mechanism was deduced. We also study the interaction of apigenin with DNA by DPV and Ultraviolet – Visible (UV) spectra. The results showapigenin doesn’t interact with DNA under the conditions.