Abstrait

Studies on biologically active transition metal complexes of N, N’-bis[1,3-benzodioxol-5-ylmethylene]butane-1,4-diamine

Prasad M.Alex, K.K.Aravindakshan

The Co(II),Ni(II) and Cu(II) complexes of the bidentate chelating Schiff base ligand, N,NÂ’-bis-1,3-benzodioxol-5-ylmethylene]butane-1,4-diamine were synthesised using acetates, chlorides, bromides, nitrates and perchlorates of the metals. They were characterised by elemental analysis, conductance and magnetic susceptibility measurements UV-Vis and IR spectra, and thermogravimetric analysis. The thermograms of three complexes were analysed and the kinetic parameters for the different stages of decompositions were determined. The in vitro antibacterial activity against gram-positive Bacillus subtilis and gram-negative Escherichia coli and in vitro antifungal activity against Aspergillus ficuum and Candida albicans of three complexes and the lignad were investigated.