Abstrait

Stability indicating methods for determination of Naftidrofuryl Oxalate

Samah S.Abbas, Hala E.Zaazaa, Mohamed R.El-Ghobashy, Yasmin M.Fayez, Soheir A.Fattah

First derivative ratio and densitometry were used to determine Naftidrofuryl Oxalate (NFL) in presence of its alkaline degradate (I). For first derivative ratio, the peak amplitude at 249.2 nm was used for selective determination of NFL in presence of I in the range of 10-90 µg mL-1, while utilizing densitometric technique allows selective determination of NFL in presence of I in range of 0.6-8 µg spot-1. The suggested methods were used to determine NFL in synthetic mixtures and in commercial tablets. The validity of the proposed methods was further assessed by applying standard addition technique. The obtained results were statistically compared with official HPLC method, showing no significant difference with respect to accuracy and precision.