Abstrait

Spectrophotometric simultaneous determination of olmesartan medoxomil and amlodipine besylate in combined tablet dosage form

A.R.Chabukswar, A.H.Kategaonkar, B.S.Kuchekar, S.C.Jagdale, P.D.Lokhande, S.N.Shinde

A simple, economical, precise and accurate method for simultaneous determination of Olmesartan medoxomil (OLME) and Amlodipine besylate (AMLO) in combined tablet dosage form has been developed. The method is based on ratio spectra derivative Spectrophotometry. The amplitudes 216.99 nm and 246 nm in the first derivative of the ratio spectra were selected to determineOlmesartanmedoxomil andAmlodipine besylate respectively in combined formulation. BeerÂ’s law is obeyed in the concentration range of 8-24gmL-1 forOLME and 2-6gmL-1 forAMLO. The%assay for commercial formulationwas found to be 100.03±0.717 for OLME and 99.94 ± 0.744 forAMLO. The method was validated with respect to linearity, precision and accuracy.