Abstrait

Spectrophotometric estimation of tolterodine tartarate in tablet dosage form

R.Maheswari, S.Indira Devi, S.Dhanalakshmi, B.Sabitha, M.Shaiba

Validated spectrophotometric methods (MethodAand B) for the estimation of Tolterodine tartarate in tablet formulations are described. Method A involved estimation by simple UV spectrophotometry and in method B the drug was treated with Folin ciocalteau reagent and estimated by visible spectrophotometry. Tolterodine tartarate is a competitivemuscarinic receptor antagonist, used for treating urinary incontinence. The drug exhibited maximum absorbance at 282 nm and 742 nm for method A and B, respectively. The calibration plots were found to be linear in the concentration ranges of 50 to 250g/ml and 10 to 60g/ml, with regression values of 0.9998 and 0.9987 for method A and B, respectively. The methods were validated by performing recovery studies, precision and by determining limits ofmeasurement.With the values obtained the methodswere found to be accurate and precise.