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Simultaneous estimation of dicyclomine hydrochloride and diclofenac sodium in bulk and in tablets by UV-spectrophotometry

DeepshriA.Bhamare, Ganesh B.Patil, Sanjay B.Bari, DilipA.Patil

A simple UV-spectrophotometric method has been developed for the simultaneous estimation of dicyclomine hydrochloride and diclofenac sodium in bulk and its formulation. The VierodtÂ’s method implemented for the formation and solving simultaneous equations. The absorbance maxima of dicyclomine and diclofenac used were 267nm and 280 nm, respectively. The Calibration curves were linear with correlation coefficient of 0.997 and 0.999 over the concentration range of 2-10 ìg/mL and 5-25ìg/ mL for dicyclomine and diclofenac respectively. The mean percent recovery was found to be 100.46±1.09 and 100.47±1.45 for dicyclomine and diclofenac respectively. The method is validated according to ICH guidelines. From the results, one can state that, the method was is precise, accurate and sensitive. The present developed method was successfully applied for routine laboratory analysis of drugs.