Abstrait

Simple spectrophotometric determination of desloratadiene from pharmaceutical formulation

R.V.Rele, S.A.Sawant, R.N.Mali

Simple sensitive and accurate extractive spectrophotometric methods have developed for the estimation of desloratadine in pharmaceutical dosage form. The methods are based on the formation of coloured complexes by the drug with reagents like bromophenol blue, solochrome dark blue, bromocresol green and congo red in acidic medium. The ion associated complexeswere formed and quantitatively extracted under the experimental condition in chloroform. The absorbance valueswere measured at 420 nm, 495 nm, 430 nmand 400 nmrespectively. The proposedmethodswere validated statistically. Recoveries of methods were carried out by standard addition methods. The linearitywas found to be 1.0-5.0g/ml, 2.5-25g/ml, 2.5-30g/ ml and 10-60g/ml formethods 1, 2, 3 and 4 respectively. The lowvalues of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of desloratadine in tablets.