Abstrait

Protective effect of matrine against cerebral ischemia reperfusion Injury in rats

Xiaochun Peng, Kun Zhang, Hongying Ma

Objective:To investigate the effects of matrine on expression of SOD and NO in rats with global cerebral ischemia reperfusion injury and provide the evidences for further study. Methods. The models were made by transient bilateral occlusion of the common carotid artery (CCA) and hypotension lasting for 10 min according to the method of Smith. Forty male Sprague- Dawley (SD) rats weighing 260^ÿ300g were randomly divided into the sham-operation groupÿthe model groupÿthe matrine group (20, 40, 60 mg/ kg). Matrine was immediately administered in matrine group by intraperitoneal injection after ischemia-reperfusion. Saline water was administered in the other two groups by the same procedures. 24 hours later, the rats were sacrificed and brain tissues were isolated for the test of SOD, NO factors by color matching method. Results:The levels of SOD, NO in model group were higher than those in sham-operation group (P <0.05). But compared withmodel group, the levels of SOD were increased and NO in matrine group were decreased (P<0.05). Conclusion: Matrine can defend the brain ischemia reperfusion injury by alleviating the oxidative stress reaction