Abstrait

Parathyroid functions and trace metal elements in hemodialysis patients

Abdullah Sivrikaya, Esma Menevse, Ali Muhtar Tiftik, Zeki Tonbul

Objective: The aim of the study was determine whether there were an important differences in levels of Ca (calcium),Mg (magnesium), P (phosphorus), cholesterol, HDL-cholesterol, triglyceride, and plasma PTH (parathyroid hormone) between hemodialysis and healthy groups, besides whether there were any correlations between elements, lipid profiles and PTH in all groups. Material and methods: The study included 47 hemodialysis patients who were dialyzed with a range of 2-16 years. This group called as a “Hemodialyis group”. Blood samples were taken before (pre-hemodialysis) and after (post-hemodialysis) hemodialysis session. “Control group” included 23 healthy volunteers. Results: PTH (p = 0.01), Mg (p = 0.001) levels were lower and HDLcholesterol (p = 0.001) levels were higher in group of control than prehemodialysis. Levels of PTH (p = 0.05) were higher in post-hemodialysis than the control group. Mg (p = 0.001) and P (p = 0.01) levels were significantly higher and cholesterol, triglyceride (p = 0.05), HDL-cholesterol (p = 0.001) levels were lower in pre-hemodialysis patients than post-hemodialysis patients. In patients pre- and post-hemodialysis, a positive correlation between P and Cholesterol (respectively r = 0.553, r = 0.679, p = 0.001) were determined. In pre-hemodialysis patients, correlation between Ca and triglyceride were negative (r = -0.392, p = 0, 05). In control group, correlation between PTH andMg were (r = 0.509, p = 0.05) statistically significant. Conclusions: Our findings indicated that the levels of Mg, P, cholesterol, HDL-cholesterol and triglyceride altered during dialysis session. PTH levels showed significant differences when we compared the groups of control and pre-, post-hemodialysis. Moreover, the correlation between P and cholesterol levels in hemodialysis groups demonstrated that there were association between P and cholesterol. Further extensive studies are necessary to clarify the effect of P levels on lipid parameters.