Abstrait

Novel phytochemical constituents identified from the seeds of Mesua ferrea L: Chemical Characterization and Antimicrobial Activity

B. K Mehta, Faizan Danish khaleel, Darshana Mehta and Masood Ayoub Kaloo

Novel Phytochemical constituents were isolated from the unsaponifiable matter extracted from seeds of Mesua ferrea with the help of n- hexane solvent. The three known compounds, two new aromatic esters and two new oleanane- type pentacyclic triterpenoidal saponins, were identified by spectral (IR,1H NMR,13C NMR spectra, mass spectrum, elemental analysis) and chemical analysis. The identified aromatic esters namely, 5- formyl-2- (propan-2-yl) phenyl acetate, 2,4-diformyl-6-(propan-2-yl) phenyl acetate, and two new oleanane- type pentacyclic triterpenoidal saponins identified were 2α,3β-28 olenolic acid and 2α,3β-28 ursanolic acid (FIGURE 1). Antimicrobial activities were assessed for all these isolated compounds. Antimicrobial activities were assessed for the isolated compounds, and variable activities were observed. Among these some of the compounds showed significant zone of inhibition against B. subtilis and P. vulgaris, while one of these compounds exhibit remarked antifungal activity against A. niger and A. flavus. To the best of our knowledge, for the first time these novel compounds and being reported along with their antimicrobial properties.