Abstrait

New Spectrophotometric Methods For The Determination Of Cefetamet In Pharmaceutical Preparations

B.H.M.Mruthyunjayaswamy, Basavaraj Hiremath

Two sensitive and simple spectrophotometric methods for the determination of cefetamet have been described in this paper. The method is based on the interaction of diazotized cefetamet with N-(1-naphthyl) ethylenediamine dihydrochloride(NEDA) in neutral or 1-naphthol(1NPL) in alkaline medium. Absorbance of the resulting chromophores is measured at 553 nm or 556 nm respectively. The two coupling reagents are applied successfully for the determination of cefetamet in tablets. The common excipients used as additives in pharmaceutical preparations do not interfere with the determinations. Results from the analysis of pure cefetamet and its commercial tablet by the proposed methods agree well with the reported method.