Abstrait
Isolation, characterization and synthesis of novel impurity in antiviral drug: Valacyclovir hydrochloride
Keshava Navin Kumar Reddy, VVNKV Prasadaraju, S.Ashok, Mayur D.Khunt, Bojju Ramachandra Reddy, Vurimidi Himabindu, Ghanta Mahesh Reddy
During the process development of valacyclovir hydrochloride (1), one novel impuritywas detected inHPLC analysis. This impuritywas isolated, synthesized and characterized as 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin- 9-yl)methoxy]ethyl-N-(acetyl)-L-valinate (2), by 1H NMR, IR and mass spectral data.
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