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Irreversible Biamperometry Determination Of Penicillamine Based On A Flow-Injection Analysis

Li Li-Jun, Cheng Hao, Chen Qi-Feng, Huang Wen-Yi

An original flow-injection coupling irreversible biamperometric method is developed for the direct determination of penicillamine. The method depends on electrocatalytic oxidation of penicillamine at a gold electrode and the reduction of permanganate at a platinum electrode to form an irreversible biamperometric detection system. Under the applied potential difference of 0 V, in the 0.05mol/L sulfuric acid, penicillamine can be determined over the range 6.00×10-5-1.00×10-3 mol L-1with a sampling frequency of 80 samples per hour. The detection limit for penicillamine is 8.0×10-6 mol L-1 and the RSD for 19 replicate determinations of 4.0× 10-4 mol/L penicillamine is 2.89%. The proposed method was applied to the analysis of penicillamine in penicillamine tablets with satisfactory results.