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Formulation and in vitro Evaluation of Ethyl Cellulose Floating Microspheres

Akhil P. Maske, S. M. Patil, S. S. Dongare, G. N. Sapkale and Anil P. Maske

The present study aim towards formulation and in vitro evaluation of floating microspheres by oral drug delivery system. The main objective of study is to develop sustained release floating microsphres of diltiazem hydrochloride by using non-aqueous emulsification solvent evaporation method. The experimental work was done as per preformulation study of diltiazem hydrochloride i.e.calibration curve of drug in 0.1 N HCl and IR analysis of drug and polymer like ethyl cellulose 10 cps. Evaluation study of floating microsphere are characterized by micromeretics properties such as particle size, percentage yield, taped density, flow property, percentage floating, percentage drug entrapment, dissolution study and advanced study that is of drug and polymer, SEM of floating microsphere.