Abstrait

Enhancement of Dissolution Rate of Aceclofenac by Solid Dispersion Technique

T. V. Rao and S. Vidhyadhara

Aceclofenac, a selective cyclooxygenage inhibitor is used in the treatment of rheumatoid arthritis and ankylosing spondylitis. One of the major problems with the drug is that, it is practically insoluble in water, which results in poor bioavailability after oral administration. In the present study, solid dispersions of aceclofenac were prepared by solvent evaporation method with two hydrophilic carriers such as poly vinyl pyrrolidine (PVPk-30), and PEG-6000 were used in the ratio of (drug : carrier) 1 : 1, 2 : 1, and 3 : 1, respectively. Prepared solid dispersions were subjected to IR study for determining any interaction between drug and carriers. Study showed no interaction between drug and carriers. Solid dispersions were subjected for determination of percentage drug content, particle size analysis and in vitro dissolution study. The dissolution rate studies were performed in phosphate buffer pH 6.8 using USP XXII type-2 apparatus. Solid dispersion in the ratio of 2 : 1 (Drug : PVPk-30) gave faster dissolution rate than other SDs, corresponding physical mixtures and pure drug.