Abstrait

Enamines as a precursor for synthesized of some azoles and azines with expected biological activity

Mohamed G.Assy, Enaiat K.Mohamed, Amira A.Ghoneim, Islam Ragab

Pyrimidinthione (3) and pyridinthione derivative (4) are obtained fromthe reaction of enamine (1) with benzoyl isothiocyanate. Condensation of compound (3) with ethyl acetate afforded quinoxaline derivative (6). pyridinothiothiazole (7) was prepared by the reaction of compound (4) with sodium hypochloride.Alkylation of compound (4) with chloro acetic acid yielded thienopyridine (9). Condensation of 4 with diethyl oxalate afforded pyridopyridine derivative (11). heterocyclo condensation of benzylidene cyanoacetamide derivative and enamine (1) yielded hydroxypyridene (12). Addition of benzylidene malononitrile to enamine (1) yielded 4H-pyridone (13). Compound (1) was reacted with potassium isothiocyanate affording oxathiazol (15) and with ethyl cyano acetate afforded pyridinone derivative (16). The structures of the new products were confirmed on the basis of elemental and spectral data. Some of the synthesized compounds were screened as antibacterial and antifungal.