Abstrait

Development of new antitubercular drugs containing benz-fused ring system

Mohammad Asif

Complicated composition of the mycobacterial cell wall, therapy of tuberculosis is very difficult, becauseMycobacterium tuberculosismakesmany antibiotics and drugs ineffective and hinders the entry of drugs. Now, tuberculosis is still the second most imperative infectious disease worldwide. The most important reason for this is drug resistant, persistent or latent infection and synergismof tuberculosis with HIV. Furthermore various chemical entities containing drugs has come in the treatment of tuberculosis. These drugs are mainly containing different heterocyclic moiety both in fused or substituted form. In present review we discussed brief introduction of tuberculosis followed the substituted benz-fused compounds including currently used drugs and newly developed molecules which are effective against tuberculosis.