Technologie chimique : une revue indienne
ISSN (PRINT):0974-7443

Abstrait

Development and Validation of RP-HPLC Method for Quantitative Analysis of Gabapentin in Pure and Pharmaceutical Formulations

R. B. Desireddy, P. Jitendra Kumar, G. Naga Sowjanya, P. Prachet, Ch. Vijay Kumar, G. Suresh Kumar and K. Srinivas Rao


A validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Gabapentin in pure and pharmaceutical formulations. Method was carried on Zodiac C18 column (250 mm × 4.6 mm × 5 µ particle size) using Methanol : Acetonitrile : Triethylamine (50 : 25 : 25) as mobile phase. Detection was carried out by U.V. at 211 nm. The proposed method obeyed linearity in the range of 10-60 µg/mL. and met all specifications as per ICH guidelines. Statistical analysis revealed that this method can be used in routine quality control studies of Gabapentin in pure and its formulations.


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