Abstrait

Determination of strontium ranelate in pure and pharmaceutical formulations by oxidimetry.

B.V.Srinivas, U.Viplava Prasad, M.L.N.Acharyulu, T.S.Reddy

Two simple and sensitive spectrohotometric methods A, B have been developed for the estimation of StrontiumRanelate. The methodAis based on oxidation of the drug with oxidant Potassium permanganate followed by the estimation of unreacted oxidant with Fast green FCF. Method B involves the addition of excess CAT of a known concentration in the presence of 0.25M HCl and determining the unreacted CAT by measuring the absorbance of the Dye Gallocyanine. The absorption maxima were found to be at (ëmax 630nmforA, 540 nmfor B). Thesemethods obey Beer.s lawlimits (2-10gml-1forA), (2-10gml-1 forB) and give reproducible results. The percentage recoveries are 99.89±0.37 to 100.31±0.59(for A), 99.55±0.77 to 100.32±0.44 (for B) respectively.