Abstrait

Correlation Study on Oxidant and Antioxidant Levels in Plasma of Acute Myocardial Infarction Among Male Patients

Ashok Narasimhan, Anbarasan Chakrapani, Sheela Sasikumar Changam, Soma Guhathakurta and Kotturathu Mammen Cherian

Aims: To evaluate and correlate the plasma concentration of oxidants and antioxidants between control and within Acute Myocardial Infarction (AMI) patients. Settings and Design: Subjects (mean age of 45-60 yrs) were divided into two equal groups with evidence of AMI (n=25) and control (n=25). The proposed molecules were estimated using standard protocol from blood samples. Methods and Material: The levels of antioxidants like vitamin E (alpha tocopherol), vitamin C (Ascorbic acid), reduced Glutathione (GSH), total protein thiols (TPT) were estimated in the plasma. Lipid peroxides, ceruloplasmin, ischemia modified albumin and protein carbonyls levels were also measured in the plasma of control and AMI patients using standard procedures. Statistical analysis used: Data from patients and controls was compared using StudentÂÂ’s‘tÂÂ’-test. Values were expressed as mean ± standard deviation (SD). SPSS software version 16.0 was used for statistical analysis. ‘pÂÂ’ value of less than 0.05 was considered to indicate statistical significance. Results: Among the comparison studies, Vitamin E antioxidant and Lipid peroxides oxidant were found to be more significantly associated with AMI patients when compared against control. Vitamin E showed strong positive relationship between ejection fraction in myocardial infarcted patients and reduced Glutathione in diabetic AMI patients. Conclusions: Plasma vitamin E and Reduced Glutathione are found to be key players in MI events which could be used as an effective biomarker and also in the treatment of cardiac events in acute myocardial infarcted individuals.