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Antiulcer potential of leaves of achyranthes aspera Linn. in rats

Vaibhav Mishra, Sunil Kumar Mishra, Samuel Adetunji Onasanwo, Gautam Palit, Abbas Ali Mahdi, Santosh Kumar Agarwal,Vijai Lakshmi

Plants have been used for medicine from time immemorial because they have fitted the immediate personal need, are easily accessible and inexpensive. In the recent past there has been a tremendous increase in the use of plant based health products in developing as well as developed countries resulting in an exponential growth of herbal products globally. Herbalmedicines have a strong traditional or conceptual base and the potential to be useful as drugs in terms of safety and effectiveness leads for treating different diseases. No studies have been reported for its antiulcer activity. Therefore, an attempt has been made to evaluate the antiulcer potential of the ethanolic extract of Achyranthes aspera Linn.. Itwas found that ethanolic extract of the leaves of A.aspera was active in various ulcer models in Sprague-dawley (SD) rats. It showed gastroprotection by following the antisecretory and cytoprotective mechanism. In anti secretory mechanism the ethanolic extract of the A.aspera was inhibiting the free and total acid in pyloric ligated ulcer models. It was showing protection in alcohol induced ulcer model and it also improved the depleted levels of mucin in pyloric ligatedmodel.