Abstrait

Anti-tumor, antioxidant and antimicrobial and the phenolic constituents of Glycyrrhizaglabra

Mohamed H.M.Abd El Azim, Amani M.D.El-Mesallamy, Mohamed El-Gerby, Ahmed Awad

Seventeen phenolic compounds were defined from the methanol extract of licorice roots (Glycyrrhizia glabra L.) by chromatographic methods. Efficiency of the methanol extract of licorice roots as anticancer agent for breast, colon and liver was tested. The results showed that the IC50 of the extract was 28.1µg / ml for anti-colon cancer and 31.3µg/ml for anti-breast cancer,while itwas 3.42µg/ml for anti-hepatic cancer. The antioxidant activity was measured by DPPH radical scavenging method. This extract showed strong antioxidant activity against DPPH as compared with vitamin C. Antimicrobial activity of the methanol extract of licorice roots was studied against three bacterial and four fungal strains at concentration 0.1ml and 0.3ml (10mg/1ml)). The extract showed strong inhibitory effect for most species at concentration 0.3ml.